Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 Italian 100+ REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 GTCT Candidate Region/Gene 22340368
    rs1800896 - rs1800629 IL10 0.038 174 vs 224 Italian >100 GG-GG (only in men) Candidate Region/Gene 12676903
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.46 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
    HP*1 F/S HP 0.82 0.33 1072 total Italian >88 Candidate Region/Gene 21147083
    rs2234693 - rs2234693 ESR1 0.12 108 vs 85 Italian 90+ Candidate Region/Gene 20819792
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    rs11279109 - APOB XbaI APOB 0.001 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ Candidate Region/Gene 17393087
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases Danish Mean age 92.8 +/- 0.4 G-C-T (haplotype) Candidate Region/Gene 20388090
    HP1/2 common polymorphism HP 0.05 200 (cases) vs 539 (initial) (initial) Italian >88 Candidate Region/Gene 21703254
    Haplogroup J 0.38 0.025 98 vs 117 Chinese 90–100 Candidate Region/Gene 18759861
    5178A,10400T mtDNA 0.387 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    3010A,5178A,10400T mtDNA 0.141 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    14979C,3010A,5178A,10400T mtDNA 0.781 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    8020A,3010A,5178A,10400T mtDNA 0.549 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    8964T,8020A,3010A,5178A,10400T mtDNA 0.319 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    9296T,8964T,8020A,3010A,5178A,10400T mtDNA 0.55 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    1107C,5178A,10400T mtDNA 0.559 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    14569A,10400T mtDNA 0.796 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    4833G,14569A,10400T mtDNA 0.949 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    7600A,4833G,14569A,10400T mtDNA 0.153 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    9824C,10400T mtDNA 0.955 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    12811C,9824C,10400T mtDNA 0.587 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    7196A,10400T mtDNA 0.847 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
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    • 25 of 87 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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