Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    e4 APOE 0.55 0.03 163 vs 1039 Spanish 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.41 0.05 79 vs 597 Italian 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.35 0.001 729 vs 498 Japanese 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.04 376 vs 376 Canadian 85+ e4 Candidate Region/Gene 24126160
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 Italian 100+ e4 e2 Candidate Region/Gene 16960022
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 Italian 100+ REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    LPA isoform LPA 0.05 84 (cases) vs 517 Japanese 80+ Lp(a)F, Lp(a)B Candidate Region/Gene 11269751
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    Cdx2–GATA haplotypes VDR 0.05 923 Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    APOE polymorphism APOE 0.0001 291 vs 589 Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    rs1800896 - rs1800629 IL10 0.038 174 vs 224 Italian >100 GG-GG (only in men) Candidate Region/Gene 12676903
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    HP 1/2 HP 1.27 0.0194 1072 total Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    HP*1 F/S HP 0.82 0.33 1072 total Italian >88 Candidate Region/Gene 21147083
    rs2234693 - rs2234693 ESR1 0.12 108 vs 85 Italian 90+ Candidate Region/Gene 20819792
    APOE haplotype - rs1346044 APOE 0.0001 175 vs 178 Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 Italian >88 e4 e2 Candidate Region/Gene 21703254
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    rs11279109 - APOB XbaI APOB 0.001 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ Candidate Region/Gene 17393087
    APOB XbaI − SI000565Q APOB 0.006 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
    rs11279109 - SI000565Q APOB 0.05 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
    rs11279109 - APOB XbaI - SI000565Q APOB 0.044 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases Danish Mean age 92.8 +/- 0.4 G-C-T (haplotype) Candidate Region/Gene 20388090
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    • 25 of 53 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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