Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs429358, rs7412 APOE 0.025 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.46 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
    rs1800591-rs61733139 MTTP 0.93 164 vs 261 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    rs429358, rs7412 APOE 0.001 179 vs 615 Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    D4a mtDNA haplogroups 0.05 112 vs 96 Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
    rs11279109 - APOB XbaI APOB 0.001 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ Candidate Region/Gene 17393087
    APOB XbaI − SI000565Q APOB 0.006 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
    rs11279109 - SI000565Q APOB 0.05 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
    rs11279109 - APOB XbaI - SI000565Q APOB 0.044 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    C4B1 C4B 0.05 77 (cases) vs 235 Italian Mean age 101 Candidate Region/Gene 10219002
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    Cdx2–GATA haplotypes VDR 0.05 923 Dutch Mean age 75.7 GG GA, AA Candidate Region/Gene 21051524
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases Danish Mean age 92.8 +/- 0.4 G-C-T (haplotype) Candidate Region/Gene 20388090
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 Italian >88 e4 e2 Candidate Region/Gene 21703254
    APOE polymorphism - HP1/2 common polymorphism APOE 0.013 200 (cases) vs 539 (initial) Italian >88 e4-H2 (haplotype) Candidate Region/Gene 21703254
    HP1/2 common polymorphism HP 0.05 200 (cases) vs 539 (initial) (initial) Italian >88 Candidate Region/Gene 21703254
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 Italian 100+ e4 e2 Candidate Region/Gene 16960022
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 Italian 100+ REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 GTCT Candidate Region/Gene 22340368
    APOE haplotype - rs1346044 APOE 0.0001 175 vs 178 Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    rs2234693 - rs2234693 ESR1 0.12 108 vs 85 Italian 90+ Candidate Region/Gene 20819792
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    • 25 of 87 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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