Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2229765 IGF-1 0.04 222 vs 288 Italian >85 G A Candidate Region/Gene 19460140
    Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 0.044 303 Human Minimum age 98 for one sibling (of sibship) Genome-Wide Association Study 11526246
    marker D4S1564 0.044 308 European min. age 98 for one sibling. 91+ males, 95+ females Genome-Wide Association Study 11526246
    rs1800591 MTTP 0.032 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591 MTTP 0.64 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
    rs61733139 MTTP 0.32 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.43 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.46 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
    rs1800591 MTTP 0.6 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.57 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.93 164 vs 261 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs2866164 MTTP 1.21 0.28 373 vs 540 1033 vs 359 German Centenarians G C Candidate Region/Gene 15911777
    rs2075650 TOMM40 2.07 2.36e-10 801 vs 914 253 vs 341 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1322048 TEK 1.27 2.94e-06 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs12629971 EIF4E3 1.61 1.9e-06 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1456669 Intergenic 1.58 4.05e-06 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs6801173 EIF4E3 1.52 8.16e-06 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs337656 Intergenic 1.31 5.74e-05 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs997675 Intergenic 1.24 1.41e-05 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2247549 Intergenic 1.69 3.2e-05 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs9899404 GIP 1.30 1.09e-05 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1340573 Intergenic 1.18 0.000391042 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs4977756 Intergenic 1.37 7.97e-06 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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