Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4880 SOD2 0.009 224 vs 441 Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs1801133 MTHFR 0.029 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 C Candidate Region/Gene 15621215
    rs4880 SOD2 0.009 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 T Candidate Region/Gene 15621215
    rs5882 CETP 3.56 0.001 213 vs 258 Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    rs2229765 IGF-1 0.04 222 vs 288 Italian >85 G A Candidate Region/Gene 19460140
    rs1800591 MTTP 0.032 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.32 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591 MTTP 0.6 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.57 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs2866164 MTTP 1.21 0.28 373 vs 540 1033 vs 359 German Centenarians G C Candidate Region/Gene 15911777
    rs10149689 TSHR 1.56 0.001 232 vs 163 Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs12050077 TSHR 1.32 0.01 366 vs 163 Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs10149689 TSHR 1.22 0.08 366 vs 163 Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs1800795 IL-6 0.007 323 (cases) vs 377 (initial) Italian median age = 101 G C Candidate Region/Gene 11500818
    rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
    rs28969505 YTHDF2 0.047 136 vs 275 Italian Mean age 101 15-15 (205 bp) Candidate Region/Gene 16799135
    rs6457452 HSP70-A1B 1.0 347 vs 238 American, Ashkenazi Jewish Minimum age 100 Candidate Region/Gene 17027907
    rs675 APOA4 0.05 58 vs 100 Italian Mean age 102,3 A (NCBI) Candidate Region/Gene 9622284
    rs2430561 IFNG 0.02 174 vs 248 Italian >99 T (females) Candidate Region/Gene 11772518
    rs2229765 IGF1R 0.03 218 vs 278 Italian 98 AA or AG Candidate Region/Gene 12843179
    rs2297626 FOXO1A 0.512 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs2297627 FOXO1A 0.495 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs3745544 INSR 0.441 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
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    • 25 of 375 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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