Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2229765 IGF-1 0.04 222 vs 288 Italian >85 G A Candidate Region/Gene 19460140
    rs1800591 MTTP 0.032 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.32 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591 MTTP 0.6 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.57 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.93 164 vs 261 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs2866164 MTTP 1.21 0.28 373 vs 540 1033 vs 359 German Centenarians G C Candidate Region/Gene 15911777
    rs10149689 TSHR 1.56 0.001 232 vs 163 Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs12050077 TSHR 1.32 0.01 366 vs 163 Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs10149689 TSHR 1.22 0.08 366 vs 163 Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs1800795 IL-6 0.007 323 (cases) vs 377 (initial) Italian median age = 101 G C Candidate Region/Gene 11500818
    DRD4 7R allele DRD4 3.5e-08 310 vs 2909 European mean age 95.2 years Candidate Region/Gene 23283341
    rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
    ACE genotype ACE 0.716 102 vs 7232 Korean Mean age 102 Candidate Region/Gene 12634288
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 Italian age 99–109,years, mean age 101 years; 26 men, 111 women Candidate Region/Gene 16799135
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 Italian age 99–109,years, mean age 101 years; 26 men, 111 women Candidate Region/Gene 16799135
    rs28969505 YTHDF2 0.047 136 vs 275 Italian Mean age 101 15-15 (205 bp) Candidate Region/Gene 16799135
    APOE4 APOE 0.013 35 vs 125 Chinese 90 years or over High E4 frequency Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    E4 APOE 0.013 35 vs 125 Chinese 90 years or over Candidate Region/Gene 11780357

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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