Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


  • Variant effect: + -
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    Populations | Study Types | Variant Types



    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    CTSD CTSD 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    AGT AGT 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    TP53 TP53 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    DRD4 DRD4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    SLC6A4 SLC6A4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    rs11066301 PTPN11 0.0111 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    rs1042571 POMC 0.0874 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    rs3212948 ERCC1 0.1062 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    rs1800591 MTTP 0.032 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.32 525 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs61733139 MTTP 0.57 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs1800591 MTTP 0.6 379 vs 251 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.93 164 vs 261 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs2866164 MTTP 1.21 0.28 373 vs 540 1033 vs 359 German Centenarians G C Candidate Region/Gene 15911777
    ACE genotype ACE 0.716 102 vs 7232 Korean Mean age 102 Candidate Region/Gene 12634288
    APOE e2,e3,e4 APOE 0.05 185 vs 486 Finn Over 100 E4 e2 Candidate Region/Gene 8018664
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs5882 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    I carriers of ACE 0.045 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    rs147610191 APOA4 0.05 229 vs 571 Calabrian 81–109 (median 101) Candidate Region/Gene 12556235
    APOC3-SstI-RFLP (3'UTR, 3238 nt) APOC3 0.05 229 vs 571 Calabrian 81–109 (median 101) Candidate Region/Gene 12556235
    −438 G/A TAFI 0.53 0.003 2224 American, Caucasian 65+ G (men) Candidate Region/Gene 15939070
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    • 25 of 382 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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