Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (153)   Locus (2)   Haplotype (31)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    APOE e2/e4 APOE 2.00 0.001 300 vs 160 — French 100+ e4 e2 Candidate Region/Gene 8136829
    rs4340 ACE 1.90 0.001 300 vs 160 — French 100+ I D Candidate Region/Gene 8136829
    Apo C-I 1>2 Apo C-I — 0.05 282 vs 200 — British 84+ Apo C-I 2 — Candidate Region/Gene 9105559
    - APOC1 — 0.05 282 vs 200 — British 84 and over — — Candidate Region/Gene 9105559
    APOE e2,e3,e4 APOE 9.24 0.01 224 vs 441 — Ashkenazi Jewish 75 e4 e2 Candidate Region/Gene 15621215
    ApaI IGF2 — 0.063 224 vs 441 — Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
    rs4880 SOD2 — 0.009 224 vs 441 — Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    rs1801133 MTHFR 6.00 0.014 224 vs 441 — Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    R353Q F7 — 0.045 224 vs 441 — Ashkenazi Jewish 75 A G Candidate Region/Gene 15621215
    rs429358, rs7412 APOE — 0.025 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs1801133 MTHFR — 0.029 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — C Candidate Region/Gene 15621215
    rs4880 SOD2 — 0.009 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — T Candidate Region/Gene 15621215
    A/G IGF2 — 0.063 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 — A, AA Candidate Region/Gene 15621215
    - F5 — 0.045 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 A — Candidate Region/Gene 15621215
    rs282070 MAP3K7 — 0.0011 288 vs 554 — Calabrian 90+, median 92 G — Candidate Region/Gene 22576335
    rs2111699 GSTZ1 — 0.0014 288 vs 554 — Calabrian 90+, median 92 A — Candidate Region/Gene 22576335
    rs5882 CETP 3.56 0.001 213 vs 258 — Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    rs2229765 IGF-1 — 0.04 222 vs 288 — Italian >85 G A Candidate Region/Gene 19460140
    rs10149689 TSHR 1.56 0.001 232 vs 163 — Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs12050077 TSHR 1.68 0.0001 232 vs 163 — Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs12050077 TSHR 1.32 0.01 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs10149689 TSHR 1.22 0.08 366 vs 163 — Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs1800795 IL-6 — 0.007 323 (cases) vs 377 (initial) — Italian median age = 101 G C Candidate Region/Gene 11500818
    DRD4 7R allele DRD4 — 3.5e-08 310 vs 2909 — European mean age 95.2 years — — Candidate Region/Gene 23283341
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 — Italian age 99–109,years, mean age 101 years; 26 men, 111 women — — Candidate Region/Gene 16799135
    • Page 1 of 14
    • 25 of 344 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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