Longevity Variant Database

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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2271528 SDAD1 1.02e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs2444861 C8orf47 8.99e-06 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs2710548 FAT4 2.79e-05 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs3125524 3.83e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs3210458 ACPL2 1.52e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs3764650 ABCA7 0.135 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs3818361 CR1 0.563 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs3851179 PICALM 0.227 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    rs3865444 CD33 0.442 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs4280854 3.85e-05 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs429358 + rs7412 APOE 0.04 1236 vs 326 Chinese 60+ e4 non-e4 Candidate Region/Gene 9792194
    rs4673651 ERBB4 6.08e-06 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs4686837 ST6GAL1 4.6e-05 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs4720752 RPA3 1.93e-05 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs4859571 NAAA 1.56e-05 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs610932 MS4A6A 0.176 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs6454676 2.9e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs6491207 4.63e-05 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs6532496 PDLIM5 4e-05 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs680109 GRIA4 2.52e-05 1364 American, British Age range 50-108; mean age at death 80.2 C A Genome-Wide Association Study 22445811
    rs6962026 PSCD3 2.07e-05 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs7103504 CNTN5 4.39e-05 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs744373 BIN1 0.689 1364 American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    rs7525717 5.76e-06 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs7622678 BDH1 1.93e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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