Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (1027)   No Age Effect (543)  
  • Study type: + -
    GWAS (2)   ‑ (27)   Candidate Region/Gene (784)   Meta‑Analysis (38)   Complete Mitochondrial Genome (2)   Whole‑Genome Linkage Scan (1)   Genome‑Wide Association Study (710)   Mitochondrial Haplogroup (36)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (572)   Locus (5)   Haplotype (87)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs132793 XRCC6 — 0.74 224 vs 293 170 vs 220 Caucasian, European 90-103, 98+ (replication) — — Candidate Region/Gene 21972126
    rs1008438 HSPA1A — 0.005 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    rs1061581 HSPA1B — 0.04 157 vs 62 — Danish 92.8 A — Candidate Region/Gene 16804002
    −174 G/C Interleukin 6 — 0.6 2224 — American, Caucasian 65+ G — Candidate Region/Gene 15939070
    −455 G/A FGB — 0.56 2224 — American, Caucasian 65+ — — Candidate Region/Gene 15939070
    rs2234693 ESR1 — 0.08 108 vs 85 — Italian 90+ PP (genotype) — Candidate Region/Gene 20819792
    rs1800795 IL6 — 0.006 244 vs 309 138 vs 98 Italian 85+ CC (genotype) — Candidate Region/Gene 19377912
    apoE haplotypes — — 0.02 80 vs 391 — Greek 80+ Apo e4 — Candidate Region/Gene 17234815
    ?60H LMP2 — 0.756 157 vs 311 — Italian 88+ H — Candidate Region/Gene 11772516
    ?145K LMP7 — 0.849 157 vs 311 — Italian 88+ K — Candidate Region/Gene 11772516
    apoE haplotypes — — 0.0042 3924 — American 5-70 Apo e4 — Candidate Region/Gene 21332925
    Mitochondrial haplogroups mtDNA — 0.001 225 (cases) vs 400 middle aged vs 257 infants — Finn 90-91 H U, J, K Mitochondrial Haplogroup 12483296
    rs11235972 UCP3 — 0.029 908 vs 708 — Danish 93 A — Candidate Region/Gene 22743239
    rs1685354 UCP3 — 0.762 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
    rs3781907 UCP3 — 0.05 908 vs 708 — Danish 93 G — Candidate Region/Gene 22743239
    rs647126 UCP3 — 0.447 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
    LPA isoform LPA — 0.05 84 (cases) vs 517 — Japanese 80+ Lp(a)F, Lp(a)B — Candidate Region/Gene 11269751
    82133 G>A — — 0.0189 33 vs 39 — Japanese 90+ A — Candidate Region/Gene 15820493
    5-HTTLPR SLC6A4 — 0.03 15 male, 53 female centenarians (cases) — Australian, Caucasian 101.0 ± 0.2 L/L (only for males) — Candidate Region/Gene 22985157
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE — 0.013 35 old vs 71 young vs 54 MI patients — Chinese 90 apoE4 — Candidate Region/Gene 11780357
    rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
    SV-6 CLU — 1.0 49 vs 27 vs 20 — Greek, Italian 99–107 — — Candidate Region/Gene 16804001
    I550V Human Indy homolog — 0.0551 17 vs 1321 — African American, Asian, Caucasian, Hispanic 90-99 A G Candidate Region/Gene 14499494
    rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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