Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


  • Variant type: + -

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    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K Candidate Region/Gene 23354683
    rs1815739 ACTN3 1.03 0.1 59 vs 283 Caucasian, Spaniard centenarians (aged 100–108 years) Candidate Region/Gene 21407828
    J mtDNA haplogroup 0.027 138 vs 138 Spaniard >85 (oldest age group) 18931934
    rs2107538-rs2280789 RANTES 4.90 0.03 104 vs 110 Spaniard Mean age 89.6 non A-T haplotypes A-T Candidate Region/Gene 22265023
    rs1937 TFAM 0.003 107 vs 284 Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
    rs2107538 RANTES 3.20 0.029 104 vs 110 Spaniard Mean age 89.4 A G Candidate Region/Gene 22265023
    rs2107538-rs2280789 RANTES 0.04 104 vs 110 Spaniard Mean age 89.6 non G-C haplotypes G-C Candidate Region/Gene 22265023
    rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
    mtDNA haplogroups mtDNA 0.027 138 Spaniard Minimum age 85 non-J J Mitochondrial Haplogroup 18931934
    rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 (unelated Italian cohort) Spaniard Range : 100-111 K R Candidate Region/Gene 23354683
    rs2280789 RANTES 8.80 0.03 104 vs 110 Spaniard Mean age 89.5 C T Candidate Region/Gene 22265023
    • 12 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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