Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    rs708272 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    rs5882 CETP 1.0 12 vs 190 vs 105 Greek 99-111 Candidate Region/Gene 23389097
    H63D HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    S65C HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    rs3758391 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs1885472 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs2273773 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs10997870 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs2234975 SIRT1 1.0 386 vs 640 vs 547 German Mean age 101 Candidate Region/Gene 16257164
    rs1801274 FCGR2A 1.0 408 vs 446 vs 454 German Centenarians Candidate Region/Gene 16893392
    C150T mtDNA L2 1.0 556 vs. 403 Chinese 90-108 Mitochondrial Haplogroup 21262335
    rs854560 PON1 1.0 579 vs 308 Italian Over 100 Candidate Region/Gene 12082503
    CYP2D6*3 CYP2D6 1.0 552 vs 243 French mean 101 Candidate Region/Gene 9654200
    CYP2D6*4 CYP2D6 1.0 523 vs 252 French mean 101 Candidate Region/Gene 9654200
    GSTM1 deletion GSTM1 1.0 565 vs 229 French mean 101 Candidate Region/Gene 9654200
    NAT2*5A (C 481 T), NAT2*6A (G 590 A), NAT2*7A (G 857 A), and NAT2*14A (G 191 A) NAT2 1.0 188 vs 88 French mean 101 Candidate Region/Gene 9654200
    microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 0.922 493 vs 425 Chinese (females ≥ 94; males ≥ 90 Candidate Region/Gene 20199671
    codon 192 PON1 1.0 192 vs 77 Italian 56 ages 66 to 89, 96 >90 Candidate Region/Gene 16799134
    codon 55 PON1 1.0 192 vs 77 Italian 56 ages 66 to 89, 96 >90 Candidate Region/Gene 16799134
    11 different snps tested, not all given. MTTP 1.0 1398 vs 777 British 77.9 ± 0.2 Candidate Region/Gene 17339647
    (HLA)-A1, B8, DR3 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
    rs1800629 TNF 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
    rs909253 TNF 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
    rs2288377 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
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    • 25 of 543 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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