Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (39)   No Age Effect (43)  
  • Study type: + -
    ‑ (1)   Candidate Region/Gene (53)   Meta‑Analysis (1)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (31)  
  • Variant type: + -
    Haplotype « 
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs699947-(−1190G/A)-rs1570360-(−634G/C) VEGFA — 0.03 — 332 vs 648 Italian 85-99 (mean 89.8±2.8) non A-A-G-G haplotypes A-A-G-G Candidate Region/Gene 17574707
    rs11279109 - APOB XbaI - SI000565Q APOB — 0.044 191 (case) vs 53 — Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    rs429358, rs7412 APOE — 0.025 (150 m, 74 f) vs (121 m, 320 f) — Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs2107538-rs2280789 RANTES — 0.04 104 vs 110 — Spaniard Mean age 89.6 non G-C haplotypes G-C Candidate Region/Gene 22265023
    rs2107538-rs2280789 RANTES 4.90 0.03 104 vs 110 — Spaniard Mean age 89.6 non A-T haplotypes A-T Candidate Region/Gene 22265023
    rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 — Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
    rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 — Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
    HP 1/2 HP 1.27 0.0194 1072 total — Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    HP*1 F/S HP 0.82 0.33 1072 total — Italian >88 — — Candidate Region/Gene 21147083
    rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
    D4a mtDNA haplogroups — 0.05 112 vs 96 — Japanese Minimum age 105 non-D4a D4a Complete Mitochondrial Genome 18545700
    mtDNA haplogroups mtDNA — 0.027 138 — Spaniard Minimum age 85 non-J J Mitochondrial Haplogroup 18931934
    APOE polymorphism APOE — 0.437 1408 cases — Brazilian 69.3 +/- 7.2 — — Candidate Region/Gene 17934638
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 — Italian 100+ — REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    e4 APOE 0.55 0.03 163 vs 1039 — Spanish 100+ e4 — Candidate Region/Gene 24534555
    rs1800591-rs61733139 MTTP — 0.93 164 vs 261 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases — Danish Mean age 92.8 +/- 0.4 — G-C-T (haplotype) Candidate Region/Gene 20388090
    rs1800796-(−373(A)n(T)m)-rs1800795 IL6 — 0.07 1710 total — Danish 47-100 G-(−373(A)8(T)12)-C non G-(−373(A)8(T)12)-C haplotypes Candidate Region/Gene 15130757
    rs1800896 - rs1800629 IL10 — 0.038 174 vs 224 — Italian >100 — GG-GG (only in men) Candidate Region/Gene 12676903
    APOE haplotype - rs1346044 APOE — 0.0001 175 vs 178 — Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    rs429358, rs7412 APOE — 0.001 179 vs 615 — Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.03972 184 vs 184 — Italian 100 A-G-G-A non A-G-G-A haplotypes Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.9852 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1761 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.1282 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    • Page 1 of 4
    • 25 of 87 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue