Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    Haplogroup J 0.38 0.025 98 vs 117 Chinese 90–100 Candidate Region/Gene 18759861
    rs1061581-rs1043618-rs2227956 3.46 0.025 191 vs 53 Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
    rs1061581-rs1043618-rs2227956 4.51 0.016 191 vs 53 Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 Italian 100+ e4 e2 Candidate Region/Gene 16960022
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    APOE polymorphism APOE 0.0001 291 vs 589 Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    APOE haplotype - rs1346044 APOE 0.0001 175 vs 178 Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 Italian >88 e4 e2 Candidate Region/Gene 21703254
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    APOE polymorphism - HP1/2 common polymorphism APOE 0.013 200 (cases) vs 539 (initial) Italian >88 e4-H2 (haplotype) Candidate Region/Gene 21703254
    rs429358, rs7412 APOE 0.025 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs429358, rs7412 APOE 0.001 179 vs 615 Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    e4 APOE 0.55 0.03 163 vs 1039 Spanish 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.41 0.05 79 vs 597 Italian 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.35 0.001 729 vs 498 Japanese 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.04 376 vs 376 Canadian 85+ e4 Candidate Region/Gene 24126160
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 GTCT Candidate Region/Gene 22340368
    rs1800591-rs61733139 MTTP 0.61 197 vs 251 Dutch Mean age 93.8±3.1 Candidate Region/Gene 16611701
    rs1800591-rs61733139 MTTP 0.46 655 vs 244 Dutch Mean age 87.5±3.1 Meta-Analysis 16611701
    rs1800591-rs61733139 MTTP 0.93 164 vs 261 Dutch Mean age 93.8 ± 3.1 Candidate Region/Gene 16611701
    rs1800796-(−373(A)n(T)m)-rs1800795 IL6 0.07 1710 total Danish 47-100 G-(−373(A)8(T)12)-C non G-(−373(A)8(T)12)-C haplotypes Candidate Region/Gene 15130757
    rs1061581 - rs1008438 - rs2227956 Hsp70Ba 0.55 0.015 168 cases Danish Mean age 92.8 +/- 0.4 G-C-T (haplotype) Candidate Region/Gene 20388090
    rs11279109 - APOB XbaI APOB 0.001 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ Candidate Region/Gene 17393087
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    • 25 of 87 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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