Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination 3.19 0.0006 208 vs 514 Italian Mean age 96 non-AAV allele combi AAV allele combinati Candidate Region/Gene 21340542
    IL6 VNTR A/B/C/D 0.56 0.05 61 vs 94 Italian Mean age 100 B non-B Candidate Region/Gene 17506774
    marker D4S1564 0.044 308 European min. age 98 for one sibling. 91+ males, 95+ females Genome-Wide Association Study 11526246
    rs3811952, rs155979, rs3762985 0.54 0.008 137 vs 213 Korean Mean age 90 CGA Genome-Wide Association Study 19641380
    rs712700 1.87 0.01 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs327512 5.55 0.005 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs1979128 2.10 0.006 137 vs 213 Korean Mean age 90 G Genome-Wide Association Study 19641380
    rs1450740, rs1450741, rs1562818, rs1980042, rs1027989, rs 1546518, rs3968371 3.72 0.002 137 vs 213 Korean Mean age 90 CTCCGCA Genome-Wide Association Study 19641380
    Q/H 95, rs2866164 0.0005 653 (197 m, 456 f) vs non-mentioned 564 (92 m, 472 f) vs 564___(Franch Caucasians) American, Caucasian Mean 100,8 Q95 G Genome-Wide Association Study 14615589
    rs4746720 1.35 0.022 246 vs 236 Chinese 60-90 C Candidate Region/Gene 20633545
    Haplogroup J 0.38 0.025 98 vs 117 Chinese 90–100 Candidate Region/Gene 18759861
    rs16928120 0.00057 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    S61712.1 (GenBank, 3` VNTR) 0.003 143 (51 m, 92 f) vs 158 (77 m, 81 f) Italian 102 +/- 2 <35 repeats Candidate Region/Gene 9050915
    rs1061581-rs1043618-rs2227956 4.51 0.016 191 vs 53 Chinese >90 non A-G-C or non A-C-T haplotypes A-C-T Candidate Region/Gene 19840767
    rs1061581-rs1043618-rs2227956 3.46 0.025 191 vs 53 Chinese >90 non A-G-C or non A-C-T haplotypes A-G-C Candidate Region/Gene 19840767
    rs17205854 3.74e-06 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs7525717 5.76e-06 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs17049647 7.12e-06 1364 American, British Age range 50-108; mean age at death 80.2 G T Genome-Wide Association Study 22445811
    rs1418425 9.64e-06 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs1537438 2.53e-05 1364 American, British Age range 50-108; mean age at death 80.2 G T Genome-Wide Association Study 22445811
    rs11206814 2.67e-05 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs6454676 2.9e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs10485170 3.67e-05 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs3125524 3.83e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs4280854 3.85e-05 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
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    • 25 of 1027 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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