Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A 0.03972 184 vs 184 Italian 100 A-G-G-A non A-G-G-A haplotypes Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A 0.00394 184 vs 184 Italian 100 non G-G-G-C haplotypes G-G-G-C Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A 0.02249 184 vs 184 Italian 100 A-G-G-A-T-A non A-G-G-A-T-A haplotypes Candidate Region/Gene 20126416
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A 0.00211 184 vs 184 Italian 100 non G-G-G-C-C-G haplotypes G-G-G-C-C-G Candidate Region/Gene 20126416
    e4 APOE 0.55 0.03 163 vs 1039 Spanish 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.41 0.05 79 vs 597 Italian 100+ e4 Candidate Region/Gene 24534555
    e4 APOE 0.35 0.001 729 vs 498 Japanese 100+ e4 Candidate Region/Gene 24534555
    APOE haplotype - rs1346044 APOE 0.0001 175 vs 178 Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    e4 APOE 0.04 376 vs 376 Canadian 85+ e4 Candidate Region/Gene 24126160
    rs699947-(−1190G/A)-rs1570360-(−634G/C) VEGFA 0.03 332 vs 648 Italian 85-99 (mean 89.8±2.8) non A-A-G-G haplotypes A-A-G-G Candidate Region/Gene 17574707
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    rs2234693 - rs2234693 ESR1 0.12 108 vs 85 Italian 90+ Candidate Region/Gene 20819792
    9 mtDNA haplogroups mtDNA haplogroup 0.38 0.025 98 vs. 117 Chinese 90-100 years old J non-J - 18759861
    Haplogroup J 0.38 0.025 98 vs 117 Chinese 90–100 Candidate Region/Gene 18759861
    4491A,3705G,10400T mtDNA 0.027 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    5417A,10873T mtDNA 0.018 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    12358G,5417A,10873T mtDNA 0.058 463 vs 1389 Chinese >/=95 Mitochondrial Haplogroup 19641616
    rs1800896 - rs1800629 IL10 0.038 174 vs 224 Italian >100 GG-GG (only in men) Candidate Region/Gene 12676903
    mtDNA haplogroups mtDNA 7.56 0.0015 74 vs 187 Amish >80 years non-X X Mitochondrial Haplogroup 21750925
    mtDNA haplogroups mtDNA 0.40 0.0003 74 vs 187 Amish >80 years J non-J Mitochondrial Haplogroup 21750925
    rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
    rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
    HP 1/2 HP 1.27 0.0194 1072 total Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 Italian >88 e4 e2 Candidate Region/Gene 21703254
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    • 25 of 39 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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