Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian G,C T Candidate Region/Gene 19249341
    rs939915 SIRT3 0.0145 2461 samples (cases and controls combined) Italian Candidate Region/Gene 19367319
    rs11188059 CYP2C 0.04 616 centenarians versus control group of 945 younger individuals German Candidate Region/Gene 21798861
    rs4073591 DEAF1 0.002618 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs4073590 DEAF1 0.004259 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs11040489 KRTAP5-6 0.005869 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs4930001 DEAF1 0.010851 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs800140 TSPAN32 0.0081 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs16928120 0.00057 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    HRAS1 LASS1 (CCT) APOE 4.1e-05 147 vs 188 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 7.8e-05 147 vs 188 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 9.5e-05 204 vs 251 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 6.91e-07 204 vs 251 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 1e-05 128 vs 115 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 9e-06 19 vs 73 Georgian Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 0.00197 125 vs 163 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 1e-06 79 vs 88 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CCT) APOE 0.0511 68 vs 68 American Candidate Region/Gene 20569235
    HRAS1 LASS1 (CGT) APOE 1.06e-09 68 vs 68 American Candidate Region/Gene 20569235
    rs3772190 TERC 0.006 1013 total Danish A G Candidate Region/Gene 22136229
    rs12696304 TERC 0.248 1013 total Danish Candidate Region/Gene 22136229
    rs2542052 APOC3 0.001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
    rs17446593 FOXO1 0.93 0.338 1447 vs 1029 (German) 166 vs 216 (Italian) German Candidate Region/Gene 21388494
    rs1078892 FOXO1 0.96 0.589 1447 vs 1029 (German) 166 vs 216 (Italian) German Candidate Region/Gene 21388494
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    • 25 of 784 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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