Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs939915 SIRT3 0.0145 2461 samples (cases and controls combined) Italian Candidate Region/Gene 19367319
    rs1528753 8.1e-08 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs2371208 2.6e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10496799 NXPH2 1.4e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10489006 3.6e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs3757354 MYLIP 6.4e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10493513 1.5e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10493514 2.8e-06 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs6689491 2e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10493515 2.3e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10493518 3.6e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10493517 4.2e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs6657082 5.5e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs10498263 OR4Q3 8.3e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs1915501 0.00011 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs1405051 0.00014 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs6459623 IBRDC2 0.00015 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs5882 CETP 0.63 Multiethnic Meta-Analysis 24468472
    rs708272 CETP 0.53 Multiethnic Meta-Analysis 24468472
    MTP -493G/T MTP 0.854 Chinese - 23273182
    rs1078892 FOXO1 0.96 0.589 1447 vs 1029 (German) 166 vs 216 (Italian) German Candidate Region/Gene 21388494
    rs2721044 FOXO1 0.90 0.097 1447 vs 1029 (German) 166 vs 216 (Italian) German Candidate Region/Gene 21388494
    rs12865518 FOXO1 1.07 0.307 1447 vs 1029 (German) 166 vs 216 (Italian) German Candidate Region/Gene 21388494
    rs17446593 FOXO1 0.93 0.338 1447 vs 1029 (German) 166 vs 216 (Italian) German Candidate Region/Gene 21388494
    rs12696304 TERC 0.248 1013 total Danish Candidate Region/Gene 22136229
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    • 25 of 543 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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