Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated « 
  • Study type: + -
    GWAS (2)   ‑ (8)   Candidate Region/Gene (344)   Meta‑Analysis (30)   Complete Mitochondrial Genome (1)   Genome‑Wide Association Study (607)   Mitochondrial Haplogroup (7)   Mitochondrial genome (3)  
  • Variant type: + -
    SNP (243)   Locus (3)   Haplotype (39)   STR (3)   Deletion (1)   CNV (1)    (1)   VNTR (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    8899A — — 0.0016 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    152C — — 0.004 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    73G — — 0.0086 25 vs 25 — Turkish 90+ — — Mitochondrial genome 24792352
    mtDNA haplogroups mtDNA 2.01 0.003 367 vs 371 — Chinese Mean age 94.4 non-F F Mitochondrial Haplogroup 21945877
    4491A,3705G,10400T mtDNA — 0.027 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5417A,10873T mtDNA — 0.018 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12358G,5417A,10873T mtDNA — 0.058 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    mtDNA haplogroups mtDNA 7.56 0.0015 74 vs 187 — Amish >80 years non-X X Mitochondrial Haplogroup 21750925
    mtDNA haplogroups mtDNA 0.40 0.0003 74 vs 187 — Amish >80 years J non-J Mitochondrial Haplogroup 21750925
    mtDNA haplogroups mtDNA — 0.027 138 — Spaniard Minimum age 85 non-J J Mitochondrial Haplogroup 18931934
    - Insulin signaling pathway (IIS) — 0.01 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
    - Telomere maintenance pathway (TM) — 0.02 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
    3p24-22 3p24-22 — 0.037 3953 — American Minimum age 98 — — Genome-Wide Association Study 20824210
    marker D4S1564 — — 0.044 308 — European min. age 98 for one sibling. 91+ males, 95+ females — — Genome-Wide Association Study 11526246
    rs970048 Intergenic 1.77 7.17e-07 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — G Genome-Wide Association Study 21418511
    rs2075650 TOMM40 0.53 2.65e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G — Genome-Wide Association Study 21418511
    rs1893132 Intergenic 2.07 3.19e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs4110518 Intergenic 1.52 3.26e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs9827142 Intergenic 1.49 4.88e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — C Genome-Wide Association Study 21418511
    rs10490478 Intergenic 1.63 5.79e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — G Genome-Wide Association Study 21418511
    rs9868286 CCDC50 1.48 7.4e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — C Genome-Wide Association Study 21418511
    rs11122430 Intergenic 1.50 7.65e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs12548622 Intergenic 0.54 8.78e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G — Genome-Wide Association Study 21418511
    rs2290889 SYK 2.00 9.14e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 — A Genome-Wide Association Study 21418511
    rs4736209 Intergenic 0.64 9.5e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G — Genome-Wide Association Study 21418511
    • Page 1 of 42
    • 25 of 1027 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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