Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (39)   No Age Effect (43)  
  • Study type: + -
    ‑ (1)   Candidate Region/Gene (53)   Meta‑Analysis (1)   Complete Mitochondrial Genome (1)   Mitochondrial Haplogroup (31)  
  • Variant type: + -
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    Populations | Study Types | Variant Types


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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs3176343-rs3176344-rs3176349-rs1801270 CDKN1A — 0.9852 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    9824C,10400T mtDNA — 0.955 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    4833G,14569A,10400T mtDNA — 0.949 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1800591-rs61733139 MTTP — 0.93 164 vs 261 — Dutch Mean age 93.8 ± 3.1 — — Candidate Region/Gene 16611701
    7196A,10400T mtDNA — 0.847 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs3176343-rs3176344-rs3176349-rs1801270-rs1059234-rs876581 CDKN1A — 0.8 184 vs 184 — Italian 100 — — Candidate Region/Gene 20126416
    14569A,10400T mtDNA — 0.796 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    14979C,3010A,5178A,10400T mtDNA — 0.781 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    10646A,10400T mtDNA — 0.753 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1800591-rs61733139 MTTP — 0.61 197 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    12811C,9824C,10400T mtDNA — 0.587 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    1107C,5178A,10400T mtDNA — 0.559 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    9296T,8964T,8020A,3010A,5178A,10400T mtDNA — 0.55 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    8020A,3010A,5178A,10400T mtDNA — 0.549 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    13263G,7196A,10400T mtDNA — 0.485 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    rs1800591-rs61733139 MTTP — 0.46 655 vs 244 — Dutch Mean age 87.5±3.1 — — Meta-Analysis 16611701
    8684T,7196A,10400T mtDNA — 0.457 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    APOE polymorphism APOE — 0.437 1408 cases — Brazilian 69.3 +/- 7.2 — — Candidate Region/Gene 17934638
    13590A,9bp-deletion,10873T mtDNA — 0.43 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    5178A,10400T mtDNA — 0.387 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    15662G,8584A,9bp-deletion,10873T mtDNA — 0.357 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    HP*1 F/S HP 0.82 0.33 1072 total — Italian >88 — — Candidate Region/Gene 21147083
    8964T,8020A,3010A,5178A,10400T mtDNA — 0.319 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    9bp-deletion,10873T mtDNA — 0.311 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    12406A,3970T,12705C,10873T mtDNA — 0.304 463 vs 1389 — Chinese >/=95 — — Mitochondrial Haplogroup 19641616
    • Page 1 of 4
    • 25 of 87 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

    Suggest a new study Report a database issue