Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


  • Variant type: + -

  • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
    Export results (Download)

    Populations | Study Types | Variant Types



    LVDB_word_cloud.png
    logo.png
    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    (HLA)-A1, B8, DR3 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
    rs1800629 TNF 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
    rs909253 TNF 1.0 93 vs 100 Irish 80-97 years Candidate Region/Gene 12714268
    rs72533289 KIR2DS4 1.0 180 vs 180 Irish Mean age 89 Candidate Region/Gene 15130674
    rs662 PON1 1.03 0.55 Irish >/=100 Candidate Region/Gene 20362697
    55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish Irish, Italian Italian 100.8 years, Irish 89.8 years Candidate Region/Gene 15050299
    rs662 PON1 1.06 0.33 Irish >/=80 Candidate Region/Gene 20362697
    mt9055A mtDNA 0.164 129 vs 100 Irish 80-97 Mitochondrial Haplogroup 11404057
    rs662 PON1 1.06 0.086 5086 vs 4269 Irish >/=80 Candidate Region/Gene 20362697
    KIR2DS3 haplotypes KIR2DS3 0.05 100 vs 100 Irish Age range: 65-99 Candidate Region/Gene 21299522
    KIR2DL5 KIR2DL5 0.03 93 vs 100 89 vs 89 Irish 80-97 Candidate Region/Gene 15288696
    KIR2DS3 KIR2DS3 0.02 93 vs 100 89 vs 89 Irish 80-97 Candidate Region/Gene 15288696
    2437 T>C HSPA1L 0.01 129 vs 100 Irish 80–97 2437C Candidate Region/Gene 12742533
    192 (Q/R) PON1 1.30 0.007 308 vs 579 Italian, 296 vs 296 Irish Irish, Italian Italian 100.8 years, Irish 89.8 years Q Candidate Region/Gene 15050299
    192 PON1 1.26 0.007 Italian: 308 vs 579; Northern Irish: 296 vs 296 Irish Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7 Q Candidate Region/Gene 15050299
    rs429358, rs7412 APOE 0.43 0.0006 114 vs 2071 Irish >90 e4 e2 Candidate Region/Gene 11470126
    • 16 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


    Suggest a new study Report a database issue