Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    Met410Val SHC1 0.192 730 563 Human 85+ Met Candidate Region/Gene 15036421
    Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 0.044 303 Human Minimum age 98 for one sibling (of sibship) Genome-Wide Association Study 11526246
    rs28940577 MEFV 3.70 0.004 68 vs 196 vs 121 Human Minimum age 99 G A Candidate Region/Gene 16387839
    rs1333049 0.64 0.001 80 (cases) vs 258 healthy young Human 100–104 C Candidate Region/Gene 20230275
    • 4 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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