Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4537545 IL6R 3e-18 308 American, European, Ashkenazi Jewish 75.7 Candidate Region/Gene 19249341
    rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish mean age 98.2 A Candidate Region/Gene 16602826
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
    rs2542052 APOC3 0.0001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish 100+ A Candidate Region/Gene 16602826
    rs2542052 APOC3 0.0001 Centenarians (n = 213) their offspring (n = 216) vs 258 Ashkenazi Jewish Mean age 98.2 A 16602826
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs2542052 APOC3 0.001 213 old vs 216 offspring vs 258 controls Ashkenazi Jewish A Candidate Region/Gene 16602826
    rs10149689 TSHR 1.56 0.001 232 vs 163 Ashkenazi Jewish Median age 97 A G Candidate Region/Gene 19837933
    rs5882 CETP 3.56 0.001 213 vs 258 Ashkenazi Jewish 98,2 +/- 5,3 non-GG GG Candidate Region/Gene 14559957
    KL-VS KLOTHO 5.88 0.004 216 vs 309 Ashkenazi Jewish 95 years and over homozygous Candidate Region/Gene 15677572
    rs9536314 KL 0.007 216 vs 309 Ashkenazi Jewish >95 TG (genotype) Candidate Region/Gene 15677572
    rs4880 SOD2 0.009 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 T Candidate Region/Gene 15621215
    rs4880 SOD2 0.009 224 vs 441 Ashkenazi Jewish 75 C T Candidate Region/Gene 15621215
    APOE e2,e3,e4 APOE 9.24 0.01 224 vs 441 Ashkenazi Jewish 75 e4 e2 Candidate Region/Gene 15621215
    rs12050077 TSHR 1.32 0.01 366 vs 163 Ashkenazi Jewish Median age 69 A G Candidate Region/Gene 19837933
    rs1801133 MTHFR 6.00 0.014 224 vs 441 Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    Y318C PMS2 0.02 390 vs 410 Ashkenazi Jewish Centenarians Candidate Region/Gene 23376243
    rs429358, rs7412 APOE 0.025 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    rs1801133 MTHFR 0.029 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 C Candidate Region/Gene 15621215
    V465A GABRR3 0.04 390 vs 410 Ashkenazi Jewish Centenarians Candidate Region/Gene 23376243
    R353Q F7 0.045 224 vs 441 Ashkenazi Jewish 75 A G Candidate Region/Gene 15621215
    - F5 0.045 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 A Candidate Region/Gene 15621215
    Ile119Val PCMT1 0.049 40 vs 40 Ashkenazi Jewish Mean age 87.2 Candidate Region/Gene 10496068
    rs2866164 MTP 0.05 205 vs 288 Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
    rs2866164 MTTP 0.05 126 vs 288 Ashkenazi Jewish median age = 97 CG/GG Candidate Region/Gene 22496539
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    • 25 of 38 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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