Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4420638 APOC1 0.53 1.8e-10 763 vs 1085 754 vs 850 German Mean age 99.7 G Genome-Wide Association Study 21740922
    rs3800231 FOXO3 1.42 0.0002 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs16928120 0.00057 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs9400239 FOXO3 1.38 0.0007 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs479744 FOXO3 1.40 0.001 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs770087 DUSP6 1.53 0.002 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C Candidate Region/Gene 20800603
    rs4073591 DEAF1 0.002618 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    C4L*Q0 0.003 700 vs 900 German 94+ Candidate Region/Gene 24465950
    rs4073590 DEAF1 0.004259 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs7762395 FOXO3 1.38 0.005 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs11040489 KRTAP5-6 0.005869 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs6911407 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs2802288 FOXO3 1.28 0.006 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs768023 FOXO3 1.27 0.007 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs800140 TSPAN32 0.0081 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs2802290 FOXO3 1.26 0.01 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs4930001 DEAF1 0.010851 1600 samples (cases and controls combined) German, Italian Candidate Region/Gene 19367319
    rs2301582 NALP1 1.30 0.011 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C Candidate Region/Gene 20800603
    rs648802 PERP 1.29 0.012 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C Candidate Region/Gene 20800603
    rs769449 APOE 0.70 0.018 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German G 22234866
    rs13220810 FOXO3 0.78 0.02 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs1268170 FOXO3 1.24 0.02 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs11188059 CYP2C 0.04 616 centenarians versus control group of 945 younger individuals German Candidate Region/Gene 21798861
    rs473268 FOXO3 1.21 0.044 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
    rs12200646 FOXO3 1.28 0.064 388 vs 371 535 vs 553 German mean age 98.4 years Candidate Region/Gene 19196970
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    • 25 of 29 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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