Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    ASP299GLY TLR4 0.04 8 vs 8 Italian 25-50 16803999
    rs4986790 TLR4 0.61 273 vs 594 German Mean age 97.9 Candidate Region/Gene 17493663
    rs9330200 TUBB4B 6e-53 5036 American 28-70 AA, AT TT Genome-Wide Association Study 22174011
    rs1805329 RAD23B 0.72 0.0309 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs1805329 RAD23B 1.60 0.0225 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A Candidate Region/Gene 22406557
    rs2290889 SYK 2.00 9.14e-06 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs7864625 SYK 2.00 1.01e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G Genome-Wide Association Study 21418511
    rs2274471 JAK2 (for males) 1.58 0.088 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs2590504 KIAA0649 0.00854 1173 vs 570 American 85-100 C Genome-Wide Association Study 22533364
    rs1327533 SVEP1 0.000356 1173 vs 570 American 85-100 G Genome-Wide Association Study 22533364
    rs1322048 TEK 1.27 2.94e-06 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1063192 CDKN2A 1.35 1.66e-05 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs2383722 C9orf11 1.26 0.000224392 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs7853840 LRRN6C 1.43 0.000734871 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs3906146 LMX1B 1.23 0.000260059 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs750586 DOCK8 1.24 0.000691992 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3181360 TNFSF8 1.69 0.00045202 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1867102 C9orf3 1.30 0.000178417 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs10512392 EPB41L4B 1.18 0.000742667 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs12341685 TMEM2 1.01 0.004008145 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs3780223 C9orf94 1.10 0.012546995 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1555453 MOBKL2B 1.07e-05 1364 American, British Age range 50-108; mean age at death 80.2 A C Genome-Wide Association Study 22445811
    rs10901296 ABL1 2.37e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs7873259 ANKRD19 3.14 1.18e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    • 24 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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