Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2444861 C8orf47 8.99e-06 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs2738173 DEFB1 1.41 3.46e-05 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs4871976 PHYHIP 1.22 4.49e-05 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs6984496 XKR6 1.30 4.86e-05 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs6997589 SH2D4A 1.37 6.25058e-05 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs7011660 RBPMS 1.42 8.64e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs11783247 XKR6 1.28 9.44e-05 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2511703 LOC100288971 0.73 9.96e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G Genome-Wide Association Study 21418511
    rs1800392 WRN 1.19 0.000178635 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs13251813 WRN 1.84 0.0002 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs13251813 WRN 1.84 0.0002 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 G Candidate Region/Gene 22406557
    rs804283 GATA4 1.26 0.000281268 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs7825208 FGFR1 1.07 0.000283011 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs3024239 WRN 1.23 0.000323577 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs4240673 XKR6 1.28 0.000380806 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs7013313 CSMD3 1.26 0.00044704 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs6991271 KIF13B 1.15 0.000551626 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs10957071 TOX 1.16 0.001369463 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs882696 TUSC3 1.27 0.002004329 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1980042 LYN (for males) 2.10 0.006 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs2953983 POLB 1.60 0.0225 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs2953983 POLB 0.72 0.0309 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A Candidate Region/Gene 22406557
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92-93 years old A C Candidate Region/Gene 22406557
    rs1002149 GSR 0.71 0.0335 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A Candidate Region/Gene 22406557
    • 24 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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