Longevity Variant Database

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  • Variant type: + -

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs7803143 PSCD3 1.57e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs4720752 RPA3 1.93e-05 1364 American, British Age range 50-108; mean age at death 80.2 A G Genome-Wide Association Study 22445811
    rs6962026 PSCD3 2.07e-05 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs10085518 PSCD3 4.59e-05 1364 American, British Age range 50-108; mean age at death 80.2 T C Genome-Wide Association Study 22445811
    rs2267723 GHRHR 0.70 0.0001 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs2267723 GHRHR 0.70 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) G Candidate Region/Gene 22406557
    rs978739 TAS2R16 0.62 0.001 348 vs 593 Calabrian Mean age 93.82 non-AA AA Candidate Region/Gene 23133589
    rs1800795 IL-6 0.007 323 (cases) vs 377 (initial) Italian median age = 101 G C Candidate Region/Gene 11500818
    rs7799039 LEP 0.02 110 vs 120 Jordanian mean age 90.2 years C A Candidate Region/Gene 20201642
    rs2069827 IL6 0.064 1,089 vs 736 563 (longtitudinal study) Danish, Dutch 92+ Danish, 85+ Dutch A 22234866
    rs3779501 PIK3CG 0.139 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs1800795 IL6 0.23 250 vs 400 Finn >90 Candidate Region/Gene 11640949
    rs11767557 EPHA1 0.267 1364 American, British Age range 50-108; mean age at death 80.2 G A Candidate Region/Gene 22445811
    • 13 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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