Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (607)   No Age Effect (103)  
  • Study type: + -
    Genome‑Wide Association Study « 
  • Variant type: + -
    SNP (147)   Locus (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs2758331 SOD2 1.33 2.92563e-05 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs3763305 BTNL2 1.89 4.51e-05 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1327474 IFNGR1 (upstream) 1.07 5.4e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American — T — Genome-Wide Association Study 21782286
    rs3757354 MYLIP — 6.4e-05 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs697739 ATXN1 0.59 8.97e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs9397084 SYNE1 1.40 0.000104307 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs6459623 IBRDC2 — 0.00015 1345 cohort + 1087 offspring — American — — — Genome-Wide Association Study 17903295
    rs1042663 C2 1.52 0.000169165 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs3804474 FLJ33708 1.22 0.000264519 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs2242653 BAT5 1.39 0.000314783 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2269475 AIF1 1.45 0.000435495 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs524533 NFKBIE 1.29 0.000732713 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs3019435 PARK2 1.41 0.001006354 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs11153598 NT5DC1 1.06 0.00214039 801 vs 914 — Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs3800358 BTBD9 — 0.00541 1173 vs 570 — American 85-100 — T Genome-Wide Association Study 22533364
    rs2802292 FOXO3A — 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 — — Genome-Wide Association Study 21418511
    • 16 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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