Longevity Variant Database

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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs3757354 MYLIP 6.4e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs697739 ATXN1 0.59 8.97e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs6459623 IBRDC2 0.00015 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    -351A/G ESR1 0.05 148 vs 414 Polish 99.6-107.2; mean= 101.1±1.2 Candidate Region/Gene 20599431
    rs2764264 FOXO3 0.05 1089 vs 736 Danish 92–93 T Candidate Region/Gene 20849522
    rs7762395 FOXO3 0.05 1089 vs 736 Danish 92–93 G Candidate Region/Gene 20849522
    rs13217795 FOXO3 0.05 1089 vs 736 Danish 92–93 T Candidate Region/Gene 20849522
    rs9400239 FOXO3 0.05 1089 vs 736 Danish 92–93 C Candidate Region/Gene 20849522
    rs9398172 FOXO3 0.05 1089 vs 736 Danish 92–93 A Candidate Region/Gene 20849522
    rs479744 FOXO3 0.05 1089 vs 736 Danish 92–93 (can't figure out using ensemble and NCBI) Candidate Region/Gene 20849522
    rs9486913 FOXO3A 1.18 0.053 304 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 119 Candidate Region/Gene 19489743
    -397T/C ESR1 0.06 149 vs 414 Polish 99.6-107.2; mean= 101.1±1.3 Candidate Region/Gene 20599431
    rs9486902 FOXO3A 1.18 0.073 303 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 118 Candidate Region/Gene 19489743
    rs1044891 FOXO3A 1.17 0.14 298 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 113 Candidate Region/Gene 19489743
    rs361525 TNFa 0.156 See Description for details Italian Comparison 1: 66-91. Comparison 2: >88 Candidate Region/Gene 21865054
    rs1800629 TNFa 0.168 See Description for details Italian Comparison 1: 66-91. Comparison 2: >88 Candidate Region/Gene 21865054
    rs2227956 HSPA1L 0.328 168 cases Danish Mean age 92.8 +/- 0.4 Candidate Region/Gene 20388090
    rs5746098 SOD2 0.355 130 vs 135 Jordanian Mean age 90.01 Candidate Region/Gene 20003469
    rs1485780 CD2AP 0.604 1364 American, British Age range 50-108; mean age at death 80.2 C A Candidate Region/Gene 22445811
    rs1800629 TNF 0.76 250 vs 400 Finn >90 Candidate Region/Gene 11640949
    rs6457931 CDKN1A 1.01 0.936 184 vs 184 Italian 100 Candidate Region/Gene 20126416
    rs1800629 TNF 1.0 119 vs 118 Jordanian Mean age 90.2 Candidate Region/Gene 20518833
    H63D HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    S65C HFE 1.0 35 vs 106 91-105 Candidate Region/Gene 11857056
    rs2802292 FOXO3A 1.0 403 vs 1670 4149 vs 7582 Dutch mean 94 Genome-Wide Association Study 21418511
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    • 25 of 29 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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