Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (344)   No Age Effect (382)  
  • Study type: + -
    Candidate Region/Gene « 
  • Variant type: + -
    SNP (375)   Locus (3)   Haplotype (53)   Other (1)   STR (11)   Deletion (5)   CNV (1)    (1)   VNTR (1)  
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    Populations | Study Types | Variant Types


    LVDB_word_cloud.png
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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    A-3826G (rs1800592) - C-3740A UCP1 0.81 0.014 236 vs 741 — Italian >91 G-A — Candidate Region/Gene 21827845
    rs10014396 SNCA — 0.021 769 total (see notes) — Caucasian >90 (oldest age group) C — Candidate Region/Gene 22912757
    rs2866164 MTP — 0.024 318 vs 350 376 vs 506 American, Caucasian Mean age 100,8 GG — Candidate Region/Gene 18034366
    rs3775439 SNCA — 0.025 769 total (see notes) — Caucasian >90 (oldest age group) A — Candidate Region/Gene 22912757
    rs1800591 MTTP — 0.032 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    rs2866164 MTP — 0.05 205 vs 288 — Ashkenazi Jewish Mean age 97 non-CC CC Candidate Region/Gene 22496539
    Not specified IL2 — 0.05 470 vs 120 — Italian, Bulgarian Age range: 65-99 — — Candidate Region/Gene 21299522
    rs2866164 MTTP — 0.05 126 vs 288 — Ashkenazi Jewish median age = 97 CG/GG — Candidate Region/Gene 22496539
    rs2069762 IL-2 1.43 0.096 168 vs 214 — Italian Centenarians G T Candidate Region/Gene 16518704
    -330T/G IL2 1.43 0.096 168 vs 214 — Italian >99 — — Candidate Region/Gene 16518704
    rs1372519 SNCA — 0.19 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2583959 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737012 SNCA — 0.21 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs1372520 SNCA — 0.22 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619363 SNCA — 0.24 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619361 SNCA — 0.26 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2583988 SNCA — 0.26 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2737033 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2619362 SNCA — 0.27 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs2736990 SNCA — 0.31 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs61733139 MTTP — 0.32 525 vs 251 — Dutch Mean age 93.8±3.1 — — Candidate Region/Gene 16611701
    rs2866164 MTTP 1.18 0.34 666 vs 540 1033 vs 359 German <100 G C Candidate Region/Gene 15911777
    rs2572324 SNCA — 0.41 769 total (see notes) — Caucasian >90 (oldest age group) — — Candidate Region/Gene 22912757
    rs8192678 PPARGC1A — 0.469 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
    rs3736265 PPARGC1A — 0.509 122 vs 122 — Japanese mean age 106.8 — — Candidate Region/Gene 15582274
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    • 25 of 37 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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