Longevity Variant Database

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    Populations | Study Types | Variant Types



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    variants.jpg
    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs13320360 MLH1 3.13 0.0036 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92-93 years old A G Candidate Region/Gene 22406557
    rs572169 GHSR 0.72 0.0045 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2 A Candidate Region/Gene 22406557
    rs422858 AGTR1 3.57 0.007 173 vs 376 Italian 99-106 (mean 100.9±1.7) AG CC Candidate Region/Gene 22569962
    rs275653 AGTR1 3.57 0.007 173 vs 376 598 vs 422 Italian 99-106 (mean 100.9±1.7) A G Candidate Region/Gene 22569962
    rs1050450 GPX1 0.93 0.008 1613 Danish All danes born in 1905 (Danish 1905 cohort) C Candidate Region/Gene 19428448
    rs1501299 ADIPQO 0.02 110 vs 120 Jordanian mean age 90.2 years T G Candidate Region/Gene 20201642
    –11391 G/A ADIPOQ10 8.48 0.026 148 vs 414 Polish Mean age 101.1 +/- 1.2 G A Candidate Region/Gene 23339001
    rs1801282 PPARG 0.13 0.03 114 vs 173 Italian >/=90 Pro/Ala Pro/Pro, Ala/Ala Candidate Region/Gene 22985084
    rs26802 GHRL 2.34 0.032 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A Candidate Region/Gene 22406557
    rs1801282 PPARG 0.035 222 vs 250 Caucasian 86 to 109; median age 99 G Candidate Region/Gene 15236769
    V465A GABRR3 0.04 390 vs 410 Ashkenazi Jewish Centenarians Candidate Region/Gene 23376243
    (+)2019 del ADIPOQ10 0.05 118 centenarians vs 78 unrelated young Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
    ApaI IGF2 0.063 224 vs 441 Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
    rs266729 ADIPOQ10 0.08 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs2241766 ADIPQO 0.164 110 vs 120 Jordanian mean age 90.2 years G T Candidate Region/Gene 20201642
    rs1063539 ADIPOQ10 0.2 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs182052 ADIPOQ10 0.22 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs9861425 ADCY5 0.251 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs2305268 PIK3CB 0.363 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs4482616 ADCY5 0.398 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs266729 ADIPQO 0.635 110 vs 120 Jordanian mean age 90.2 years G C Candidate Region/Gene 20201642
    rs2877709 ADCY5 0.767 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs361072 PIK3CB 0.829 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs5186 AGTR1 1.15 0.875 173 vs 376 Italian 99-106 (mean 100.9±1.7) Candidate Region/Gene 22569962
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    • 25 of 31 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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