Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs10433502 FAM19A1 3.49e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs17047650 FAM19A1 3.19e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs3210458 ACPL2 1.52e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    rs4686837 ST6GAL1 4.6e-05 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs7622678 BDH1 1.93e-05 1364 American, British Age range 50-108; mean age at death 80.2 C T Genome-Wide Association Study 22445811
    (+)2019 del ADIPOQ10 0.05 118 centenarians vs 78 unrelated young Ashkenazi Jewish 95-105 A Del/Del Candidate Region/Gene 18511746
    ApaI IGF2 0.063 224 vs 441 Ashkenazi Jewish 75 G A Candidate Region/Gene 15621215
    rs1050450 GPX1 0.93 0.008 1613 Danish All danes born in 1905 (Danish 1905 cohort) C Candidate Region/Gene 19428448
    rs10510828 FHIT 1.24 0.000311601 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs10511330 ZBTB20 1.15 0.002831841 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1063539 ADIPOQ10 0.2 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs12629971 EIF4E3 1.61 1.9e-06 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs12634249 SUMF1 1.18 0.000686245 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs12721225 AGTR1 0.37 0.929 173 vs 376 Italian 99-106 (mean 100.9±1.7) Candidate Region/Gene 22569962
    rs13320360 MLH1 3.13 0.0036 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up A Candidate Region/Gene 22406557
    rs1377843 DZIP3 1.36 0.000414112 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs14576 GALNTL2 0.93 6.54e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    rs1501299 ADIPQO 0.02 110 vs 120 Jordanian mean age 90.2 years T G Candidate Region/Gene 20201642
    rs1801282 PPARG 0.035 222 vs 250 Caucasian 86 to 109; median age 99 G Candidate Region/Gene 15236769
    rs1801282 PPARG 0.13 0.03 114 vs 173 Italian >/=90 Pro/Ala Pro/Pro, Ala/Ala Candidate Region/Gene 22985084
    rs182052 ADIPOQ10 0.22 213 vs 402 Japanese minimum 95; mean 97.9 Candidate Region/Gene 18765803
    rs1834497 CLSTN2 0.00979 1173 vs 570 American 85-100 A Genome-Wide Association Study 22533364
    rs2241766 ADIPQO 0.164 110 vs 120 Jordanian mean age 90.2 years G T Candidate Region/Gene 20201642
    rs2243115 IL12A 1.11 0.001736813 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs2305268 PIK3CB 0.363 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
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    • 25 of 53 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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