Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs4673651 ERBB4 6.08e-06 1364 American, British Age range 50-108; mean age at death 80.2 G A Genome-Wide Association Study 22445811
    rs744373 BIN1 0.689 1364 American, British Age range 50-108; mean age at death 80.2 A G Candidate Region/Gene 22445811
    3'APOB-VNTR APOB 0.29 175 vs 200 Danish >100 Candidate Region/Gene 11592926
    APOB XbaI − SI000565Q APOB 0.006 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 X+ - Short X+ - Medium Candidate Region/Gene 17393087
    intron 2 VNTR IL1RN 0.08 250 vs 400 Finn >90 Candidate Region/Gene 11640949
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 Italian, Spaniard 100–111 K Candidate Region/Gene 23354683
    K153R MSTN 3.48 0.001 156 vs 384 79 vs 316 (unelated Italian cohort) Spaniard Range : 100-111 K R Candidate Region/Gene 23354683
    rs10190125 MYT1L 1.24 0.000168452 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs10194564 Intergenic (upstream of LRP1B) 1.55 8.88e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs1042571 POMC 0.0874 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    rs10496799 NXPH2 1.4e-05 1345 cohort + 1087 offspring American Genome-Wide Association Study 17903295
    rs1056836 CYP1B1 0.63 0.78 205 vs 294 German 80-89; reference group: 17-79 - 15177664
    rs11279109 - APOB XbaI APOB 0.001 191 (case) vs 53 (initial) Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ Candidate Region/Gene 17393087
    rs11279109 - APOB XbaI - SI000565Q APOB 0.044 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - X+ - Short I - X+ - Medium; D - X- - Long; D - X- - Medium Candidate Region/Gene 17393087
    rs11279109 - SI000565Q APOB 0.05 191 (case) vs 53 Chinese > 90 baseline, Mean age 97 +/- 3 D - S D - M Candidate Region/Gene 17393087
    rs1143634 IL1B 0.53 250 vs 400 Finn >90 Candidate Region/Gene 11640949
    rs11575134 IGFBP5 1.07 0.36 322 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 137 Candidate Region/Gene 19489743
    rs16944 IL1B 0.08 250 vs 400 Finn >90 Candidate Region/Gene 11640949
    rs1800587 IL1A 0.31 250 vs 400 Finn >90 Candidate Region/Gene 11640949
    rs1801123 IRS1 0.774 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs1801278 IRS1 0.337 122 vs 122 Japanese mean age 106.8 Candidate Region/Gene 15582274
    rs1898422 LRP1B 1.36 0.000323698 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs207444 XDH 0.046 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G - Unsure Candidate Region/Gene 22406557
    rs2287047 IL1R1 1.08 1.35e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    rs3769583 FLJ20272 1.31 0.001342643 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
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    • 25 of 40 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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