Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1061170 CFH 1.78 0.005 491 vs 0 Finn His 19000922
    STR variation CSF1TPO 0.003 60 vs 250 Chinese >90 low variation in STRs high variation in STRs - 20582731
    - GSTM1 0.74 94 vs 418 Italian 100 years vs 46 years - 11162685
    F5 G1691A F5 0.002 400 neonates (187 female and 312 male), 184 healthy adults (129 female and 55 male), and 432 long-lived individuals (343 women and 89 men). Polish >95 years versus 44 years - 20720309
    rs28969505 YTHDF2 2.19 0.023 137 vs 412 Italian age 99–109,years, mean age 101 years; 26 men, 111 women Candidate Region/Gene 16799135
    rs1800896 IL10 3.10 0.0003 142 vs 153 Mean age 67 AA GG Candidate Region/Gene 15466015
    Met410Val SHC1 0.192 730 563 Human 85+ Met Candidate Region/Gene 15036421
    rs1776180 EXO1 1.39 0.01 395 vs 411 455 vs 109 French, German Mean age 101.3 G C Candidate Region/Gene 19698732
    rs2476601 PTPN22 0.663 225 vs 278 Italian Mean age 93 Candidate Region/Gene 21113673
    rs1801133 MTHFR 0.01 108 (patients with CVD) vs 118 Swiss >65 C Candidate Region/Gene 10583447
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 Italian 100+ REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    rs915179-rs2485662-rs4641-rs1468772 LMNA 1.56 2.5e-05 873 vs 443 New England Centenarian Study (NECS) (N = 738), (ii) the Southern Italian Centenarian Study (SICS) (N = 905), (iii) France (N = 1103), and (iv) the Einstein Ashkenazi Longevity Study (N = 702) American, Caucasian Mean age 101.5 GTCT Candidate Region/Gene 22340368
    rs12050077 TSHR 1.68 0.0001 232 vs 163 Ashkenazi Jewish Median age 97 G A Candidate Region/Gene 19837933
    rs1800896 IL10 0.031 119 vs 118 Jordanian Mean age 90.2 G A Candidate Region/Gene 20518833
    G1691A F5 0.004 432 vs 184 Polish Minimum age 95 A G Candidate Region/Gene 20720309
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian G,C T Candidate Region/Gene 19249341
    rs1800871 IL-10 0.0026 500 Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
    rs1800896 IL10 0.019 174 vs 227 Italian >100 GG Candidate Region/Gene 12676903
    rs1801274 FCGR2A 1.0 408 vs 446 vs 454 German Centenarians Candidate Region/Gene 16893392
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs1801133 MTHFR 0.06 564 vs. 374 French mean age 100.71 TT CT, CC Candidate Region/Gene 9106548
    rs1801133 MTHFR 6.00 0.014 224 vs 441 Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    AGT AGT 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    GSTM1 deletion GSTM1 1.0 565 vs 229 French mean 101 Candidate Region/Gene 9654200
    - PARP1 1.0 239 vs 198 French >100 Candidate Region/Gene 9587069
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    • 25 of 83 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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