Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1805415 PARP1 0.66 0.001 479 vs 900 388 vs 364 African American, Caucasian G,C T Candidate Region/Gene 19249341
    rs2769255 KCNQ4 (upstream) 1.08 5.17e-06 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American T Genome-Wide Association Study 21782286
    rs1061170 CFH 1.78 0.005 491 vs 0 Finn His 19000922
    - GSTM1 0.74 94 vs 418 Italian 100 years vs 46 years - 11162685
    REN polymorphism - mtDNA mtDNA 3.27 0.006 157 Italian 100+ REN10 - mtDNA haplogroup H Candidate Region/Gene 11938442
    - GSTM1 0.54 66 vs 150 Italian 100.19±2.2 (95-105) Candidate Region/Gene 15195682
    IVS2nt-124 FASLG 0.315 50 vs 86 Italian 100.8 ± 1.8 (100 to 106) Candidate Region/Gene 11965496
    IVS3nt-167 FASLG 0.462 50 vs 86 Italian 100.8 ± 1.8 (100 to 106) Candidate Region/Gene 11965496
    rs1801274 FCGR2A 0.05 408 vs 446 vs 454 German 100–110/ mean101.3 (SNP is His/Arg) Candidate Region/Gene 16893392
    rs1800871 IL-10 0.0026 500 Japanese 56.7 years; range, 19–100 years TC TT Candidate Region/Gene 16424284
    rs1801133 MTHFR 6.00 0.014 224 vs 441 Ashkenazi Jewish 75 T C Candidate Region/Gene 15621215
    AGT AGT 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    Met410Val SHC1 0.192 730 563 Human 85+ Met Candidate Region/Gene 15036421
    rs4648884 RUNX3 0.00992 1173 vs 570 American 85-100 T Genome-Wide Association Study 22533364
    rs2495513 TMEM61 0.60 8.13e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs1538287 KCNH1 0.55 4.87e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs6701445 TAF5L 1.84 4.19e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs3211994 NTLH1 1.99 0.0056 1089 vs 736 1613 vs 1104 Danish 92-93 years old G A Candidate Region/Gene 22406557
    rs1800896 IL10 0.019 174 vs 227 Italian >100 GG Candidate Region/Gene 12676903
    - PARP1 1.0 239 vs 198 French >100 Candidate Region/Gene 9587069
    rs1800896 - rs1800629 IL10 0.038 174 vs 224 Italian >100 GG-GG (only in men) Candidate Region/Gene 12676903
    rs1801133 MTHFR 0.01 108 (patients with CVD) vs 118 Swiss >65 C Candidate Region/Gene 10583447
    mtDNA haplogroups mtDNA 7.56 0.0015 74 vs 187 Amish >80 years non-X X Mitochondrial Haplogroup 21750925
    mtDNA haplogroups mtDNA 0.40 0.0003 74 vs 187 Amish >80 years J non-J Mitochondrial Haplogroup 21750925
    STR variation CSF1TPO 0.003 60 vs 250 Chinese >90 low variation in STRs high variation in STRs - 20582731
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    • 25 of 83 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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