Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    APOE polymorphism APOE 0.0001 291 vs 589 Finn Mean age 97.5 e4 e2 Candidate Region/Gene 16487435
    APOE haplotype - rs1346044 APOE 0.0001 175 vs 178 Finn 100.8 e4 e2 Candidate Region/Gene 10069711
    APOE polymorphism APOE 3.26 0.001 64 vs 1344 Italian 100+ e4 e2 Candidate Region/Gene 16960022
    rs429358, rs7412 APOE 0.001 179 vs 615 Finn Mean age 100 e4 e2, e3 Candidate Region/Gene 8018664
    APOE polymorphism APOE 0.38 0.002 200 (cases) vs 539 Italian >88 e4 e2 Candidate Region/Gene 21703254
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90+ apoE4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 ApT4 Candidate Region/Gene 11780357
    apoE haplotypes APOE 0.013 35 old vs 71 young vs 54 MI patients Chinese 90 apoE4 Candidate Region/Gene 11780357
    APOE polymorphism - HP1/2 common polymorphism APOE 0.013 200 (cases) vs 539 (initial) Italian >88 e4-H2 (haplotype) Candidate Region/Gene 21703254
    rs429358, rs7412 APOE 0.025 (150 m, 74 f) vs (121 m, 320 f) Ashkenazi Jewish Mean age 75 e4 e2 Candidate Region/Gene 15621215
    HP1/2 common polymorphism HP 0.05 200 (cases) vs 539 (initial) (initial) Italian >88 Candidate Region/Gene 21703254
    APOE polymorphism APOE 0.437 1408 cases Brazilian 69.3 +/- 7.2 Candidate Region/Gene 17934638
    • 12 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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