Longevity Variant Database

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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs1110784 ATP9B 1.10 7.04e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American A Genome-Wide Association Study 21782286
    HUMTHO1 (STR) THO 0.05 196 (143 f, 53 m) vs 358 (296 f; 64 m) Italian >100 9-10 (long alleles, homozygous genotype) Candidate Region/Gene 9887369
    HUMTHO1 (STR), haplogroups THO, mtDNA 0.045 202 (55m, 145 f) vs 82 (43 m, 39 f) Italian 100-105 Long alleles + U haplogroup Candidate Region/Gene 11053670
    rs10401068 DOK6 1.36 9.62e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs8083511 TNFRSF11A 1.16 0.000116571 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs1991289 DSG1 1.06 0.000121161 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs1805081 NPC1 0.007 152 vs 120 Polish >100 T C Candidate Region/Gene 18834923
    rs9304496 KCTD1 1.26 0.000988927 801 vs 914 Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    • 8 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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