Denigma

Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):

  • Variant effect: + -
    Longevity‑Associated (607)   No Age Effect (103)  
  • Study type: + -
    Genome‑Wide Association Study « 
  • Variant type: + -
    SNP (147)   Locus (1)  
    • 1 2 3 4 5 6 7 8 9 10 11 12
    13 14 15 16 17 18 19 20 21 X Y MT
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    Populations | Study Types | Variant Types


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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    rs6504441 PRKCA 0.60 2.87e-06 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs9899404 GIP 1.30 1.09e-05 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs2277472 MAMDC1 1.95 7.93e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs4594173 MADMC1 1.94 9.81e-05 410 vs 553 — Italian 90–109 — — Genome-Wide Association Study 21612516
    rs7207422 ACCN1 1.34 0.000206202 801 vs 914 — Caucasian Median age 104 A G Genome-Wide Association Study 22279548
    rs1005321 HS3ST3B1 1.17 0.000337804 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs9916344 PITPNM3 1.19 0.000353663 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs205499 TRIM25 1.29 0.000424485 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs3816754 RAD51L3 1.68 0.000836276 801 vs 914 — Caucasian Median age 104 A C Genome-Wide Association Study 22279548
    rs9894254 CARD14 1.77 0.000864702 801 vs 914 — Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    • 10 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o

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