Longevity Variant Database

Narrow results by variant, study, or associated fields (e.g. gene symbol ADRB2):

Use ontology terms to further narrow results (e.g. aging, insulin, etc.):


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    Populations | Study Types | Variant Types



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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    1/s 5HTT 0.05 265 vs 225 Japanese 101.2 S Candidate Region/Gene 16095668
    mt5178A ND2 0.05 95 vs 105 Chinese Mean age 76 АА Candidate Region/Gene 12384792
    rs7214466 IGFBP4 0.90 0.094 321 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 136 Candidate Region/Gene 19489743
    rs1009728 IGFBP4 1.08 0.24 320 vs 603;279 vs 797;383 vs 363 Caucasian 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 135 Candidate Region/Gene 19489743
    I/D (insertion/deletion) ACE 0.33 560 vs 560 French centenarians 100th year or beyond, mean age 103.1 Candidate Region/Gene 11280044
    16 bp duplication in intron 3 (WT=no duplicaiton) TP53 0.59 66 vs 150 Italian 100.19±2.2 (95-105) Candidate Region/Gene 15195682
    Msp1 restriction fragment length polymorphism in intron 6 (G/A) TP53 0.65 66 vs 150 Italian 100.19±2.2 (95-105) Candidate Region/Gene 15195682
    rs4646994 ACE 0.849 399 vs 302 Chinese >90 years Candidate Region/Gene 19502260
    rs1042522 TP53 0.85 66 vs 150 Italian 100.19±2.2 (95-105) Candidate Region/Gene 15195682
    TP53 TP53 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215
    SLC6A4 SLC6A4 1.0 224 vs 441 Ashkenazi Jewish 75 Candidate Region/Gene 15621215

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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