Longevity Variant Database

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    polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
    microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 IGF1 0.922 493 vs 425 Chinese (females ≥ 94; males ≥ 90 Candidate Region/Gene 20199671
    rs2288377 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
    rs5742612 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
    rs35767 IGF1 1.0 485 vs 392 Chinese 94.92 Candidate Region/Gene 18761080
    Not specified IFNG 0.05 707 vs 339 Turkish, Polish, Italian, Bulgarian Age range: 65-99 Candidate Region/Gene 21299522
    Cdx2-GATA haplotype 1 allele Vitamin D receptor 0.78 935 participants Dutch mean age = 75.7 years Candidate Region/Gene 21051524
    rs2071069 TPI1 0.05 1422 vs 967 German mean age: 98.8, age range: 95–110 (SNP is G/A) Candidate Region/Gene 18510744
    rs2071065 TPI1 0.05 1422 vs 967 German mean age: 98.8, age range: 95–110 (SNP is T/C) Candidate Region/Gene 18510744
    rs770087 DUSP6 1.53 0.002 386 vs 410 541 vs 469 German 100 to 110, mean age = 101.3 C Candidate Region/Gene 20800603
    rs11066301 PTPN11 0.0111 288 vs 554 Calabrian 90+, median 92 Candidate Region/Gene 22576335
    rs12815289 LOC253724 0.69 5.4e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 G Genome-Wide Association Study 21418511
    rs1800802 MGP 0.77 0.132 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs10778652 CORO1C 1.08 2.18e-05 5974 (RS), 3267 (CHS), 3136 (FHS), 4511 (ARIC), 3219 (AGES), 902 (inCHIANTI), 620 (BLSA), 1661 (HABC), 1717 (SHIP) Whitehall II - 6000 (UK), English Longitudinal Study of Ageing (UK), Religious Order Study - 1100, Memory and Ageing Project American C Genome-Wide Association Study 21782286
    rs2111173 PTPRO 1.74 9.24e-05 410 vs 553 Italian 90–109 Genome-Wide Association Study 21612516
    rs11571461 RAD52 2.23 0.0001 1089 vs 736 1613 vs 1104 Danish 92.2–93.8 (mean age 93.2) A Candidate Region/Gene 22406557
    rs10047589 TXNRD1 1.46 0.043 1089 (see notes - follow-up study) 563 (see notes - follow-up study) Danish 92.2–93.8 (mean age 93.2) w/ 11.4 years follow-up G Candidate Region/Gene 22406557
    rs2291727 ADCY6 0.003 384 vs 384 579 vs 644 Chinese Mean age 102.1±0.20 Candidate Region/Gene 23020224
    rs2430561 IFNG 0.02 174 vs 248 Italian >99 T (females) Candidate Region/Gene 11772518
    rs2229765 IGF-1 0.04 222 vs 288 Italian >85 G A Candidate Region/Gene 19460140
    rs11047358 SOX5 1.47 6.49e-05 403 vs 1670 3746 vs 5912 Dutch Mean age 94 A Genome-Wide Association Study 21418511
    rs671 ALDH2 (for males) 2.11 0.009 137 vs 213 Korean Mean age 90 A Genome-Wide Association Study 19641380
    rs3782415 SOCS2 1.38 0.000284992 801 vs 914 Caucasian Median age 104 G A Genome-Wide Association Study 22279548
    rs1922263 CHST11 1.17 0.003569024 801 vs 914 Caucasian Median age 104 C A Genome-Wide Association Study 22279548
    rs4237973 PIK3C2G 1.51 0.022 137 vs 213 Korean Mean age 90 C Genome-Wide Association Study 19641380
    rs2232548 KLRF1 1.15 0.008366096 801 vs 914 Caucasian Median age 104 A C Genome-Wide Association Study 22279548
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    • 25 of 34 variants

    The Longevity Variant Database (LVDB) is a collaborative effort to catalogue all published genetic variants relevant to human longevity.

    The project is directed by the Health Extension Research Foundation [http://www.healthextension.co/about/], and the online content is managed by the members of the Global Computing Initiative.

    LVDB is driven by an international collaboration of scientists, programmers, and volunteers, including Joe Betts-LaCroix, Kristen Fortney, Daniel Wuttke, Eric K. Morgen, Nick Schaum, John M. Adams, Jessica Choi, Barry Goldberg, Amir Levine, Maria Litovchenko, Aiste Narkeviciute, Emily Quist, Navneet Ramesh, Justin Rebo, Dmitri Shytikov, and Jimi Vyas. o


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