3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR)

Polymorphism: 3' 28-base pair variable number tandem repeat (HRAS1 3'VNTR)










Location: 11p15.5

Factor:
- Symbol: HRAS
- Name: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
- Entrez ID: 3265
- Ensembl ID: ENSG00000174775

Factors:

HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog ( 3265 / ENSG00000174775 )

Description:

Polymorphism had 24 different alleles. Only 4 were compared. allele a3 = 2 Kbs. The other 20 were collectively coded as rare alleles.

Ethnicity: Italian
Age of cases: centenarians
Shorter lived allele: a3 allele (see notes)

Statistics
- Number of cases/controls: 234 vs 467 (initial)
- Odds ratio: 1.126
- p-value: 0.002 [0.002]
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR products were electrophoresed in a 2% agarose gel. molecular weight markers Markers VI and XIV (Roche) were employed, together with ad hoc molecular weight standards comprising common and rare HRAS1 3'VNTR alleles whose size was verified by autom

Reference:
11943467: An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity.

Choice: Curate
Created: July 2, 2013, 2:47 a.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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