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Denigma
»
Lifespan
»
Variants
» Variant = rs1061581 - rs1008438 - rs2227956
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Mouse Lifespan Experiments
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rs1061581 - rs1008438 - rs2227956
Polymorphism:
rs1061581 - rs1008438 - rs2227956
rs1061581
(
SNPedia
|
23andMe
)
rs1008438
(
SNPedia
|
23andMe
)
rs2227956
(
SNPedia
|
23andMe
)
Variant Type:
Haplotype
Location:
5q31.1
Factor:
- Symbol:
Hsp70Ba
- Name:
Heat-shock-protein-70Ba
- Entrez ID:
44921
- Ensembl ID:
FBgn0013277
Factors:
HSPA1A
heat shock 70kDa protein 4
(
3308
/
ENSG00000170606
)
Ethnicity:
Danish
Age of cases:
Mean age 92.8 +/- 0.4
Longer lived allele:
G-C-T (haplotype)
Finding:
Positive
Statistics
- Number of cases/controls:
168 cases (initial)
- Odds ratio:
0.55
- Odds ratio type:
Shorter
- p-value:
0.015 [0.015 (females)]
- Significant:
Yes
Study Design
- Classifications:
Longevity-Associated
- Study type:
Candidate Region/Gene
- Technology:
LightCycler system (Roche Applied Sciences), GAUSS programming package
Reference:
20388090: Anti-inflammatory heat shock protein 70 genes are positively associated with human survival.
Choice:
Clean
Created:
July 2, 2013, 2:33 a.m.
Updated:
Aug. 26, 2013, 1:44 p.m.
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