XRCC5 120 bp 5` (GAPyA)n STR

Polymorphism: XRCC5 120 bp 5` (GAPyA)n STR







Variant Type: STR
Location: 2q35


Factors:
  • XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) ( 7520 / ENSG00000079246 )


  • Description:

    The [GAPyA]n microsatellite located 120 kb 5' of XRCC5 is significantly associated with longevity. It seems that it may be rs372249446.

    Ethnicity: British
    Age of cases: Mean 70
    Shorter lived allele: 16+2
    Longer lived allele: 15
    Finding: Positive

    Statistics
    - Number of cases/controls: 430 (case) vs 290 (initial)
    - Odds ratio type: Longer
    - p-value: 0.0005
    - Significant: Yes

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: ABI Prism 310 Genetic Analyser

    Reference:
    16518718: Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity.

    Choice: Clean
    Created: July 2, 2013, 2:33 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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