192

Polymorphism: 192


Location: 7q21.3

Factor:
- Symbol: PON1
- Name: paraoxonase 1
- Entrez ID: 5444
- Ensembl ID: ENSG00000005421

Factors:
  • PON1 paraoxonase 1 ( 5444 / ENSG00000005421 )


  • Description:

    "For Italians, there was an increased frequency of QR heterozygotes and R allele in cases. For the Northern Irish, there was an increased frequency of RR homozygotes. ""...there was a small survival advantage for centenarian and

    Ethnicity: Irish
    Age of cases: Italian: Mean age 100.8 +/- 2.1; Northern Irish: Mean age 89.8 +/- 5.7
    Shorter lived allele: Q

    Statistics
    - Number of cases/controls: Italian: 308 vs 579; Northern Irish: 296 vs 296 (initial)
    - Odds ratio: 1.26
    - p-value: 0.007 [0.007]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Sequencing

    Reference:
    15050299: Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis.

    Choice: Curate
    Created: July 1, 2013, 1:04 p.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

    Edit (Admin) | Delete

    Comment on This Data Unit