rs8052394

Polymorphism: rs8052394
rs8052394 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 16q13

Factor:
- Symbol: MT1a
- Name: metallothionein 1A
- Entrez ID: 4489
- Ensembl ID: ENSG00000205362

Factors:

MT1a metallothionein 1A ( 4489 / ENSG00000205362 )

Description:

Applies only to females. Data suggests "that the AA (Asp/Asp) genotype might be considered as favourable to the longevity in old female." rs8052394 was in tight LD with rs11640851. Significant haplotype frequency difference between controls and cases was found. MT1a Arg/Asp haplotype increased in cases; MT1a Lys/Thr haplotype decreased in cases: Haplotype (Arg/Asp) might be favourable for the longevity

Ethnicity: Italian
Age of cases: Mean age 91.4 +/- 4.1
Longer lived allele: A
Finding: Positive

Statistics
- Number of cases/controls: 151 vs 100 (initial)
- Odds ratio: 2.164
- p-value: 0.0002 [0.0002]
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR based method

Reference:
16955215: Polymorphisms in MT1a gene coding region are associated with longevity in Italian Central female population.

Choice: Clean
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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