HP 1/2

Polymorphism: HP 1/2



Variant Type: Haplotype
Location: 16q22.2

Factor:
- Symbol: HP
- Name: haptoglobin
- Entrez ID: 3240
- Ensembl ID: ENSG00000257017

Factors:

HP haptoglobin ( 3240 / ENSG00000257017 )

Description:

There is a concomitant gain of HP1 allele due to association of HP1/*1 genotype with longevity. The population was divided into 3 sex-specific age classes: for men [women], Age Class 1: <66 years old [<73], Age Class 2: 66–88 [73–91], Age Class 3: >88 [>91]

Ethnicity: Italian
Age of cases: >88
Shorter lived allele: HP*2
Longer lived allele: HP*1
Finding: Positive

Statistics
- Number of cases/controls: 1072 total (initial)
- Odds ratio: 1.273
- p-value: 0.0194 [0.0194]
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Biometra T-gradient thermal-cycler

Reference:
21147083: Haptoglobin (HP) polymorphisms and human longevity: A cross-sectional association study in a Central Italy population.

Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.

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