rs4986790

Polymorphism: rs4986790
rs4986790 ( SNPedia | 23andMe )

Location: 9q33.1

Factor:
- Symbol: TLR4
- Name: toll-like receptor 4
- Entrez ID: 7099
- Ensembl ID: ENSG00000136869

Factors:

TLR4 toll-like receptor 4 ( 7099 / ENSG00000136869 )

Description:

Applies to males only. "... our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity... in German men. Therefore, the previously described associations in Sicilians might reflect either population-specific or potentially false-positive results."

Ethnicity: German
Age of cases: Mean age 97.9

Statistics
- Number of cases/controls: 273 vs 594 (initial)
- p-value: 0.61 [0.61]
- Significant: No

Study Design
- Classifications: No Age Effect
- Study type: Candidate Region/Gene
- Technology: TaqMan1 SNP Genotyping Assay (Applied Biosystems)

Reference:
17493663: Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.

Choice: Curate
Created: July 1, 2013, 1:04 p.m.
Updated: Aug. 8, 2014, 1:06 p.m.

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