rs2866164

Polymorphism: rs2866164
rs2866164 ( SNPedia | 23andMe )

Location: 4q24

Factor:
- Symbol: MTP
- Name: microsomal triglyceride transfer protein
- Entrez ID: 4547
- Ensembl ID: ENSG00000138823

Factors:
  • MTP microsomal triglyceride transfer protein ( 4547 / ENSG00000138823 )


  • Description:

    "MTP CC genotype is significantly overrepresented in centenarians .. However, ... we observed a monotonic decline between ages 55–85 years followed by a dramatic enrichment after age 90 years, forming a U-shape pattern (p < .05). "

    Ethnicity: Ashkenazi Jewish
    Age of cases: Mean age 97
    Shorter lived allele: non-CC
    Longer lived allele: CC

    Statistics
    - Number of cases/controls: 205 vs 288 (initial)
    - p-value: 0.05 [0.05]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR

    Reference:
    22496539: Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.

    Choice: Curate_Emily
    Created: July 1, 2013, 10:42 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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