AAT M/Z/S

Polymorphism: AAT M/Z/S



Location: 14q32.1

Factor:
- Symbol: AAT
- Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
- Entrez ID: 5265
- Ensembl ID: ENSG00000197249

Factors:
  • AAT serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 ( 5265 / ENSG00000197249 )


  • Description:

    Centenarians vs Acute Myocardial Infarction patients vs Young controls

    Ethnicity: Italian
    Age of cases: Centenarians
    Shorter lived allele: M, S
    Longer lived allele: Z

    Statistics
    - Number of cases/controls: 143 vs 255 vs 127 (initial)
    - Odds ratio: 0.185
    - p-value: 1e-07 [1e-07]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: Not described

    Reference:
    17048073: Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity.

    Choice: Curate_Emily
    Created: July 1, 2013, 10:42 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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