G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination

Polymorphism: G/A-IGF1R, Gly/Asp-IRS2, and Ala/Val-UCP2 allele combination










Description:

Candidate gene

gene symbol = Interactions of IGF1R, IRS2 and UCP2 (invalid literal for int() with base 10: '3480, 8660, 7351')

entrez gene id = 3480, 8660, 7351 (invalid literal for int() with base 10: '3480, 8660, 7351')

Ethnicity: Italian
Age of cases: Mean age 96
Shorter lived allele: non-AAV allele combi
Longer lived allele: AAV allele combinati

Statistics
- Number of cases/controls: 208 vs 514 (initial)
- Odds ratio: 3.185
- p-value: 0.0006
- Significant: Yes

Study Design
- Classifications: Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: PCR and restriction analysis

Reference:
21340542: A/ASP/VAL allele combination of IGF1R, IRS2, and UCP2 genes is associated with better metabolic profile, preserved energy expenditure parameters, and low mortality rate in longevity.

Choice: Curate_Johnny
Created: June 30, 2013, 11:58 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.

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